DISEASES

Disease-gene associations mined from literature

Literature on FBXW5

FBXW5 [ENSP00000313034]

F-box and WD-40 domain-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway; F-box and WD repeat domain containing

Synonyms:  FBXW5,  FBXW5p,  hFBXW5,  A0A024R8H7,  Q969U6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM