DISEASES

Disease-gene associations mined from literature

Literature on MAP3K11

MAP3K11 [ENSP00000309597]

Src-homology 3 domain-containing proline-rich kinase; Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Synonyms:  MAP3K11,  MAP3K11p,  hMAP3K11,  A0A024R5E6,  B4DS76 ...

Linkouts:  STRING  Pharos  UniProt  OMIM