DISEASES

Disease-gene associations mined from literature

Literature on ABHD2

ABHD2 [ENSP00000268129]

Abhydrolase domain-containing protein 2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. May also play a role in smooth muscle cells migration (By similarity); Abhydrolase domain containing

Synonyms:  ABHD2,  ABHD2p,  hABHD2,  A0A024RC89,  H3BMT2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM