DISEASES

Disease-gene associations mined from literature

Literature on PON3

PON3 [ENSP00000265627]

Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family.

Synonyms:  PON3,  PON3p,  hPON3,  C9JZ99,  F2Z2L3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM