DISEASES

Disease-gene associations mined from literature

Literature on ESPL1

ESPL1 [ENSP00000257934]

Extra spindle pole bodies homolog 1 (S. cerevisiae); Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.

Synonyms:  ESPL1,  ESPL1p,  hESPL1,  H3BM31,  H3BRX7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM