DISEASES

Disease-gene associations mined from literature

Literature on ORC2

ORC2 [ENSP00000234296]

Origin recognition complex, subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin- mediated proteasomal degradation. Also stabilizes ORC3; Belongs to the ORC2 family.

Synonyms:  ORC2,  ORC2p,  hORC2,  A0A024R411,  B8ZZ80 ...

Linkouts:  STRING  Pharos  UniProt