DISEASES

Disease-gene associations mined from literature

Literature on TNRC6A

TNRC6A [ENSP00000379144]

Trinucleotide repeat-containing gene 6A protein; Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes; Belongs to the GW182 family.

Synonyms:  TNRC6A,  LOC102724266,  TNRC6Ap,  hTNRC6A,  G8JLL8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM