DISEASES

Disease-gene associations mined from literature

Literature on SRGAP1

SRGAP1 [ENSP00000347198]

SLIT-ROBO Rho GTPase activating protein 1; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42; F-BAR domain containing

Synonyms:  SRGAP1,  SRGAP1p,  hSRGAP1,  G5EA48,  Q7Z6B7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM