DISEASES

Disease-gene associations mined from literature

Literature on GRM5

GRM5 [ENSP00000306138]

Glutamate receptor, metabotropic 5; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity; Glutamate metabotropic receptors

Synonyms:  GRM5,  GRM5p,  hGRM5,  A8K5P7,  A8MT20 ...

Linkouts:  STRING  Pharos  UniProt  OMIM