DISEASES

Disease-gene associations mined from literature

Literature on CAPRIN2

CAPRIN2 [ENSP00000298892]

Cytoplasmic activation/proliferation-associated protein 2; Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.

Synonyms:  CAPRIN2,  CAPRIN2p,  hCAPRIN2,  CAPRIN2-001,  CAPRIN2-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM