DISEASES

Disease-gene associations mined from literature

Literature on SMURF1

SMURF1 [ENSP00000354621]

SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Plays a role in dendrite formation by melanocytes.

Synonyms:  SMURF1,  SMURF1p,  hSMURF1,  D6W5S0,  Q9HCE7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM