DISEASES

Disease-gene associations mined from literature

Literature on TRIM58

TRIM58 [ENSP00000355437]

RING-type E3 ubiquitin transferase TRIM58; E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization; Ring finger proteins

Synonyms:  TRIM58,  TRIM58p,  hTRIM58,  Q8NG06,  Q8NG06p ...

Linkouts:  STRING  Pharos  UniProt