DISEASES

Disease-gene associations mined from literature

Literature on PEG3

PEG3 [ENSP00000326581]

Zinc finger and SCAN domain-containing protein 24; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family.

Synonyms:  PEG3,  PEG3p,  hPEG3,  M0QXG1,  M0QZD4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM