DISEASES

Disease-gene associations mined from literature

Literature on CISH

CISH [ENSP00000409346]

Cytokine inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity); SH2 domain containing

Synonyms:  CISH,  Q9NSE2,  G18,  Q9NSE2p,  hQ9NSE2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM