DISEASES

Disease-gene associations mined from literature

Literature on MX2

MX2 [ENSP00000333657]

Interferon-regulated resistance GTP-binding protein MxB; Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.

Synonyms:  MX2,  MX2p,  hMX2,  C9JEL4,  C9JS04 ...

Linkouts:  STRING  Pharos  UniProt  OMIM