DISEASES

Disease-gene associations mined from literature

Literature on DLL4

DLL4 [ENSP00000249749]

Drosophila Delta homolog 4; Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate.

Synonyms:  DLL4,  DLL4p,  hDLL4,  Q9NR61,  Q9NR61p ...

Linkouts:  STRING  Pharos  UniProt  OMIM