DISEASES

Disease-gene associations mined from literature

Literature on PLCG1

PLCG1 [ENSP00000244007]

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration; C2 domain containing phospholipases

Synonyms:  PLCG1,  PLCG1p,  hPLCG1,  M0QX77,  P19174 ...

Linkouts:  STRING  Pharos  UniProt  OMIM