Disease-gene associations mined from literature

Literature on JOSD1

JOSD1 [ENSP00000216039]

Josephin domain-containing protein 1; Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity; MJD deubiquinating enzymes

Synonyms:  JOSD1,  JOSD1p,  hJOSD1,  A0A024R1P5,  B0QY55 ...

Linkouts:  STRING  Pharos  UniProt  OMIM