DISEASES

Disease-gene associations mined from literature

Literature on DKK2

DKK2 [ENSP00000285311]

Dickkopf WNT signaling pathway inhibitor 2; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity); Belongs to the dickkopf family.

Synonyms:  DKK2,  DKK2p,  hDKK2,  D6RCC2,  D6RGF1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM