DISEASES

Disease-gene associations mined from literature

Literature on DUSP26

DUSP26 [ENSP00000256261]

Low-molecular-mass dual-specificity phosphatase 4; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK); Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Synonyms:  DUSP26,  DUSP26p,  hDUSP26,  E5RHD0,  Q9BV47 ...

Linkouts:  STRING  Pharos  UniProt