DISEASES

Disease-gene associations mined from literature

Literature on MANF

MANF [ENSP00000432799]

Mesencephalic astrocyte-derived neurotrophic factor; Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

Synonyms:  MANF,  A8K878,  P55145,  A8K878p,  hA8K878 ...

Linkouts:  STRING  Pharos  UniProt  OMIM