DISEASES

Disease-gene associations mined from literature

Literature on CYP2C8

CYP2C8 [ENSP00000360317]

Cytochrome P450, family 2, subfamily C, polypeptide 8; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol).

Synonyms:  CYP2C8,  CYP2C8p,  hCYP2C8,  B7Z1F5,  E9PIW6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM