DISEASES

Disease-gene associations mined from literature

Literature on BAX

BAX [ENSP00000293288]

BCL2-associated X protein; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis; Belongs to the Bcl-2 family.

Synonyms:  BAX-001,  BAX-002,  BAX-003,  BAX-004,  BAX-005 ...

Linkouts:  STRING  Pharos  UniProt  OMIM