DISEASES

Disease-gene associations mined from literature

Literature on PTGDR2

PTGDR2 [ENSP00000332812]

Chemoattractant receptor-homologous molecule expressed on Th2 cells; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses; CD molecules

Synonyms:  PTGDR2,  PTGDR2p,  hPTGDR2,  Q9Y5Y4,  CRTH2 ...

Linkouts:  STRING  Pharos  UniProt