DISEASES

Disease-gene associations mined from literature

Literature on PSMB11

PSMB11 [ENSP00000386212]

Proteasome (prosome, macropain) subunit, beta type, 11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity); Belongs to the peptidase T1B family.

Synonyms:  PSMB11,  PSMB11p,  hPSMB11,  A5LHX3,  A5LHX3p ...

Linkouts:  STRING  Pharos  UniProt  OMIM