DISEASES

Disease-gene associations mined from literature

Literature on ACOT8

ACOT8 [ENSP00000217455]

Peroxisomal acyl-coenzyme A thioester hydrolase 1; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20). Inactive towards substrates with more than C20 aliphatic chains. Involved in the metabolic regulation of peroxisome proliferation.

Synonyms:  ACOT8,  ACOT8p,  hACOT8,  ACOT8-001,  ACOT8-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM