DISEASES

Disease-gene associations mined from literature

Literature on SFRP4

SFRP4 [ENSP00000410715]

Frizzled protein, human endometrium; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.

Synonyms:  SFRP4,  SFRP4p,  hSFRP4,  C9JMJ2,  Q6FHJ7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM