Literature on PARP14
ADP-ribosyltransferase diphtheria toxin-like 8; ADP-ribosyltransferase. By mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation. Mono-ADP- ribosylates STAT6 (By similarity). Enhances STAT6-dependent transcription (By similarity). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation. Mono-ADP- ribosylates PARP9; Poly(ADP-ribose) polymerases
Synonyms: PARP14, PARP14p, hPARP14, H7C5R8, Q460N5 ...