DISEASES

Disease-gene associations mined from literature

Literature on PARP16

PARP16 [ENSP00000261888]

ADP-ribosyltransferase diphtheria toxin-like 15; Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono- ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP- ribosyltransferases; Poly(ADP-ribose) polymerases

Synonyms:  PARP16,  PARP16p,  hPARP16,  A0A024R5Y7,  Q8N5Y8 ...

Linkouts:  STRING  Pharos  UniProt