DISEASES

Disease-gene associations mined from literature

Literature on UNC5B

UNC5B [ENSP00000334329]

P53-regulated receptor for death and life protein 1; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity); I-set domain containing

Synonyms:  UNC5B,  UNC5Bp,  hUNC5B,  Q8IZJ1,  UNC5B-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM