DISEASES

Disease-gene associations mined from literature

Literature on PHGDH

PHGDH [ENSP00000358417]

D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D- glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Synonyms:  PHGDH,  O43175,  PGDH3,  PHGDH-001,  PHGDH-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM