DISEASES

Disease-gene associations mined from literature

Literature on GRK4

GRK4 [ENSP00000381129]

G protein-coupled receptor kinase GRK4; Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Synonyms:  GRK4,  GRK4p,  hGRK4,  D6REW5,  P32298 ...

Linkouts:  STRING  Pharos  UniProt  OMIM