DISEASES

Disease-gene associations mined from literature

Literature on RCHY1

RCHY1 [ENSP00000321239]

Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity; Ring finger proteins

Synonyms:  RCHY1,  RCHY1p,  hRCHY1,  D6RAF6,  G3FDP4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM