DISEASES

Disease-gene associations mined from literature

Literature on CXCR1

CXCR1 [ENSP00000295683]

High affinity interleukin-8 receptor A; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity; C-X-C motif chemokine receptors

Synonyms:  CXCR1,  CXCR1p,  hCXCR1,  P25024,  CMKAR1 ...

Linkouts:  STRING  Pharos