DISEASES

Disease-gene associations mined from literature

Literature on AIF1

AIF1 [ENSP00000365227]

Ionized calcium-binding adapter molecule 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation; EF-hand domain containing

Synonyms:  AIF1,  AIF1p,  hAIF1,  IBA1,  199 ...

Linkouts:  STRING  Pharos