DISEASES

Disease-gene associations mined from literature

Literature on FGD4

FGD4 [ENSP00000394487]

FYVE, RhoGEF and PH domain-containing protein 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity); Pleckstrin homology domain containing

Synonyms:  FGD4,  FGD4p,  hFGD4,  B7Z493,  E9PJX4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM