DISEASES

Disease-gene associations mined from literature

Literature on PRKRA

PRKRA [ENSP00000318176]

Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity); Belongs to the PRKRA family.

Synonyms:  PRKRA,  B4DJC7,  C9JMM3,  F8WEG8,  G5E9Q4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM