DISEASES

Disease-gene associations mined from literature

Literature on SLC27A2

SLC27A2 [ENSP00000267842]

Solute carrier family 27 (fatty acid transporter), member 2; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family.

Synonyms:  SLC27A2,  SLC27A2p,  hSLC27A2,  G3V1R7,  O14975 ...

Linkouts:  STRING  Pharos  UniProt  OMIM