DISEASES

Disease-gene associations mined from literature

Literature on MKL1

MKL1 [ENSP00000347847]

Megakaryoblastic leukemia (translocation) 1; Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity); Myocardin family

Synonyms:  MKL1,  MKL1p,  hMKL1,  B0QY74,  B0QY83 ...

Linkouts:  STRING  Pharos  UniProt  OMIM