DISEASES

Disease-gene associations mined from literature

Literature on MED17

MED17 [ENSP00000251871]

Thyroid hormone receptor-associated protein complex 80 kDa component; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Synonyms:  MED17,  MED17p,  hMED17,  E9PJZ4,  E9PKQ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM