DISEASES

Disease-gene associations mined from literature

Literature on ASIC3

ASIC3 [ENSP00000297512]

Neuronal amiloride-sensitive cation channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Synonyms:  ASIC3,  ASIC3p,  hASIC3,  H7C4W0,  Q9UHC3 ...

Linkouts:  STRING  Pharos  UniProt