DISEASES

Disease-gene associations mined from literature

Literature on MAFG

MAFG [ENSP00000350369]

V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Synonyms:  MAFG,  A0A024R8X1,  I3L2F8,  O15525,  I3L2F8p ...

Linkouts:  STRING  Pharos