DISEASES

Disease-gene associations mined from literature

Literature on FARP2

FARP2 [ENSP00000264042]

FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing

Synonyms:  FARP2,  FARP2p,  hFARP2,  LOC102724304,  C9JVQ5 ...

Linkouts:  STRING  Pharos  UniProt