DISEASES

Disease-gene associations mined from literature

Literature on NOC2L

NOC2L [ENSP00000317992]

Nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing

Synonyms:  NOC2L,  NOC2Lp,  hNOC2L,  Q9Y3T9,  NIR ...

Linkouts:  STRING  Pharos