DISEASES

Disease-gene associations mined from literature

Literature on SUZ12

SUZ12 [ENSP00000316578]

Chromatin precipitated E2F target 9 protein; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Synonyms:  SUZ12,  SUZ12p,  hSUZ12,  J3QQW9,  Q15022 ...

Linkouts:  STRING  Pharos  UniProt  OMIM