DISEASES

Disease-gene associations mined from literature

Literature on RAC3

RAC3 [ENSP00000304283]

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner; Endogenous ligands

Synonyms:  RAC3,  RAC3p,  hRAC3,  J3KSC4,  J3QLK0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM