DISEASES

Disease-gene associations mined from literature

Literature on SOCS6

SOCS6 [ENSP00000381034]

Suppressor of cytokine signaling 4; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor; SH2 domain containing

Synonyms:  SOCS6,  SOCS6p,  hSOCS6,  A0A024R379,  J3KTM7 ...

Linkouts:  STRING  Pharos