DISEASES

Disease-gene associations mined from literature

Literature on UVSSA

UVSSA [ENSP00000374501]

UV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.

Synonyms:  UVSSA,  DKFZP434C189,  Q2YD98,  Q69YU2,  KIAA1530 ...

Linkouts:  STRING  Pharos  UniProt