DISEASES

Disease-gene associations mined from literature

Literature on FBXL3

FBXL3 [ENSP00000347834]

F-box and leucine-rich repeat protein 3A; Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex; F-box and leucine rich repeat proteins

Synonyms:  FBXL3,  FBXL3p,  hFBXL3,  C9J0Y7,  FBXL3-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM