DISEASES

Disease-gene associations mined from literature

Literature on LILRB1

LILRB1 [ENSP00000315997]

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Synonyms:  LILRB1,  LILRB1p,  hLILRB1,  D9IDM5,  LILRB1-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM